ISSN 1662-4009 (online)

ey0019.5-13 | Translational highlights | ESPEYB19

5.13. C-type natriuretic peptide-induced PKA activation promotes endochondral bone formation in hypertrophic chondrocytes

K Hirota , T Hirashima , K Horikawa , A Yasoda , M Matsuda

Endocrinology 163, bqac005. (2022).Abstract: https://pubmed-ncbi-nlm-nih-gov/35041746/In Brief: C-type natriuretic peptide (CNP) is known to stimulate enchondral bone formation, but the distinct cellular pathways and cellular targets are unclear. This study used in vivo and in vitro biosensor systems to identify cGMP-induced activation of PKA as a major effect of CNP with growth promoting e...